Graphpad prism 6 manual
The CSS rates were 68.3% at 3 years, 48.5% at 5 years, and 37.1% at 8 years for the delayed resection group and 79.2% at 3 years, 67.2% at 5 years, and 65.9% at 8 years for the simultaneous resection group (HR, 1.45 95% CI, 1.14-1.98 P = .004). The OS rates were 65.2% at 3 years, 47.1% at 5 years, and 38.0% at 8 years for the delayed resection group and 78.0% at 3 years, 65.4% at 5 years, and 63.1% at 8 years for the simultaneous resection group (hazard ratio, 1.42 95% CI, 1.10-1.85, P = .003). The percentage of major perioperative complications did not differ between the simultaneous and delayed resection groups (34.1% vs 30.0% P = .89). Matching yielded 495 pairs of patients underwent simultaneous resection. Results Among the 1569 patients included, 1057 (67.4%) underwent delayed resection (719 men with a mean age of 57.4 years), and 512 patients (310 men with a mean age of 57.1 years) underwent simultaneous resection. Secondary outcomes were intraoperative and postoperative complications, overall survival (OS), and cancer-specific survival (CSS) rates. Main Outcomes and Measures Primary outcome was the percentage of patients with at least 1 major complication within 60 days after surgery. Follow-up was completed on August 31, 2021, and the data were analyzed from April 1 to 30, 2022. A 1:1 propensity score matching was performed. Objective To investigate the outcomes of simultaneous vs delayed resection in patients with resectable SLM.ĭesign, Setting, and Participants This comparative effectiveness research study included 1569 patients with resectable SLM who underwent curative-intent liver resection at 3 independent centers in China between January 1, 2000, to December 31, 2019. Importance Simultaneous or delayed resection of synchronous liver metastasis (SLM) with primary colorectal cancer (CRC) remains a controversial topic.